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hSOAT (SLC10A6)

The human sodium dependent organic anion transporter (SOAT) shows highly specific transport activity for sulfated steroids. SOAT substrates identified so far include dehydroepiandrosterone sulfate, 16α-hydroxydehydroepiandrosterone sulfate, estrone-3-sulfate, pregnenolone sulfate, 17β-estradiol-3-sulfate, and androstenediol sulfate. In humans SOAT is predominantly expressed in the testis with lower expression in the placenta and breast tissue. In the testis, SOAT was localised to spermatocytes and round spermatids and, therefore, this carrier is supposed to play a role in testicular steroid regulation and male fertility.

Main localization:	Testis, placenta, pancreas
Transporter assay:	Uptake transporter assay (potential substrate and inhibitor)
Probe substrates:	Estrone-3-sulfate (ES)
Probe inhibitors:	Sulfobromophthalein (BSP), rifampicin
Regulatory relevance:	−
Important interacting drugs:	Rifampicin, BSP

Inhibitory effect on hSOAT mediated Estrone-3-sulfate uptake of different inhibitors (100 µM)