PortaCellTec biosciences GmbH

Family SLCO

The physiological, pharmaceutical and pathological role of human Organic Anion Transporting Polypeptides  (OATPs) of the SLCO Family


General overview

OATP transporters are found in the animal kingdom only and are encoded by genes of the solute carrier organic anion transporter (SLCO) superfamily, which in humans includes 11 members. Based on hydropathy analyses, all OATPs contain 12 transmembrane domains, but this has not been proven experimentally for any OATP. The mechanism of substrate transport via OATP transporters is not completely understood, though a recent computational study suggested that OATPs translocate their substrates through a central, positively charged pore in a so-called rocker-switch type of mechanism. OATP-mediated transport is independent of sodium, chloride and potassium gradients, membrane potential and ATP levels.


Driving force and mechanism of drug transport by OATPs
OATP
The cellular uptake via OATP transporters is believed to occur by electroneutral exchange, in which the cellular uptake of organic anions is coupled to the efflux of neutralizing anions such as bicarbonate, glutathione or glutathione-S-conjugates. However, the nature of the neutralizing ion remains unknown for human OATPs.

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News

New validated products:

  • MRP2
  • roct1

Events

2nd German Pharm-Tox Summit
Heidelberg, Germany
March 06-09, 2017

19th Barrier- and
Transporter-Meeting

Bad Herrenalb, Germany
May 15-17, 2017

14th European ISSX Meeting
Köln, Germany

June 26- 29, 2017

2nd Symposium on Transporters in Drug Discovery
London, UK
May 15-16, 2017



Münster Transporttage 2017
Münster, Germany
October 21 – 22, 2017

 


Guidance for Industry (FDA and EMA)

Publications