PortaCellTec biosciences GmbH

Drug uptake transporter

Gene  name Protein  name Expression / Localization Substrates endogenous Substrates exogenous
SLC10A1 NTCP liver, pancreas bile acid, ES, DHEA-S BSP
SLC10A2 ASBT kidney, ileum, bile, small intestine bile acids, taurocholate dimeric bile acid analogues, benzothiazepine derivates
SLC10A6 SOAT1 testis, placenta, pancreas, heart, lung, liver, spleen, small intestine, colon ES, DHEA­-S, PREG-S,
bile acid sulfate
 
SLC13A3 NaDC-3 kidney, liver, pancreas, brain, placenta succinate, citrate,
α-keto-glutarate,
L-glutamate
 
SLC15A1 PEPT1 intestine, kidney di-, and tripeptids cefadroxil, amoxicillin, enalapril
SLC15A2 PEPT2 Kidney, lung, brain,
bronchial epithelium
di-, and tripeptids cefadroxil, amoxicillin, fosinopril
SLC22A1 OCT1 liver, kidney organic cations acyclovir, amantadine,
desipramine, ganciclovir, metformin
SLC22A2 OCT2 kidney, brain organic cations amantadine, cimetidine, memantine
SLC22A3 OCT3 kidney, liver, skeletal muscle, placenta, heart, lung, brain organic cations cimetidine
SLC22A4 OCTN1 kidney, skeletal muscle, placenta, prostata organic cations ergothioneine
SLC22A5 OCTN2 skeletal muscle, kidney, heart, brain organic cations L-carnitin
SLC22A6 OAT1 kidney, placenta, brain organic anions penicillin, torasemid, acyclovir, methotrexate, zidovudine, PAH
SLC22A7 OAT2 liver, kidney

cGMP, GMP,
2-deoxyguanosine

bumetanide, cyclothiazide, methotrexate, diclofenac, indomethacin, mefenamate
SLC22A8 OAT3 kidney, liver, brain, skeletal muscle, developing bone organic anions, ES,
DHEA-S
cimetidine, methotrexate, zidovudine, PAH
SLC22A11 OAT4 kidney,  placenta organic anions, ES,
DHEA-S
ochratoxin
SLC47A1 MATE1 liver, kidney organic cations TEA, MPP, metformin
SLC47A2 MATE2-K kidney organic cations TEA, MPP, metformin
SLCO1A2 OATP1A2 brain, kidney, liver ES,
DHEA-S
fexofenadine, oubain, tauroursodeoxycholate
SLCO2A1 OATP2A1 ubiquitous prostaglandin prostaglandin-E2
SLCO1B1 OATP1B1 liver bile salts, taurocholate, ES BSP, benzylpenicillin, pravastatin, rosuvastatin, rifampicin, methotrexate
SLCO1B3 OATP1B3 liver bile salts, taurocholate BSP, fluvastatin, pravastatin, pitavastatin, methotrexan
SLCO2B1 OATP2B1 liver, kidney, intestine,
brain, placenta, heart
ES,
DHEA-S, PREG-S
pravastatin, fexofenadine, atorvastine

BSP = sulfobromophthalein
DHEA-S = dehydroepiandrosterone-sulfate
MPP = 1-methyl-4-phenylpyridinium
PAH = para-aminohippuric acid
PREG-S = pregnenolone sulfate
TEA = tetraethylammonium

PortaCellTec

News

New validated products:

  • mNtcp
  • mOct1

Events

3rd German Pharm-Tox Summit
Göttingen, Germany
26 February - 1 March 2018


Pharmaforum
Saarbrücken, Germany
8 March 2018

 

AAPS Workshop
Virginia, USA
16 - 18 April 2018

 

20th Barrier- and
Transporter-Meeting

Bad Herrenalb, Germany
7 - 9 May 2018

Greifswalder Transporttage 2018
Greifswald, Germany
October 2018

 


Guidance for Industry (FDA and EMA)

Publications