The human organic anion transporter OAT2 (SLC22A7) is highly expressed in the liver at the sinusoidal membrane of hepatocytes and at lower level in the kidney. OAT2 possess with high affinity nucleobases particularly the cyclic nucleotide cGMP. Thus is involved in the regulation of cGMP concentration in renal proximal tubule cells and hepatocytes. Furthermore OAT2 is contributing in the secretion of various endogenous and exogenous compounds.
Concentration dependent inhibition of hOAT2-mediated cGMP uptake by the probe inhibitor indomethacin