PortaCellTec biosciences GmbH

MATE2-K

Three major splice variants of human MATE2 have been identified, MATE2, MATE2-B and MATE2-K. Human MATE2-K consists of 566 amino acids and is mainly expressed in the kidney, where it is localized in the luminal membrane of proximal tubular epithelial cells.
MATE1 and MATE2-K have similar substrate and inhibitor specificities, which overlap with those of OCTs, so the OCT substrates MPP and TEA are also transported by MATEs. Endogenous substrates include e.g. creatinine, guanidine and estrone sulfate. Furthermore many clinically used drugs have been shown to interact with MATE transporters. Identified substrates and drugs are metformin, cimetidine, oxaliplatin, acyclovir, and fexofenadine.

Figure 1 Kinetic of the interaction of MPP with hMATE2-K in HEK293 cells Figure 2 Kinetic of the interaction of metformin with hMATE2-K in HEK293 cells



 

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