PortaCellTec biosciences GmbH


Three major splice variants of human MATE2 have been identified, MATE2, MATE2-B and MATE2-K. Human MATE2-K consists of 566 amino acids and is mainly expressed in the kidney, where it is localized in the luminal membrane of proximal tubular epithelial cells.
MATE1 and MATE2-K have similar substrate and inhibitor specificities, which overlap with those of OCTs, so the OCT substrates MPP and TEA are also transported by MATEs. Endogenous substrates include e.g. creatinine, guanidine and estrone sulfate. Furthermore many clinically used drugs have been shown to interact with MATE transporters. Identified substrates and drugs are metformin, cimetidine, oxaliplatin, acyclovir, and fexofenadine.

Figure 1 Kinetic of the interaction of MPP with hMATE2-K in HEK293 cells Figure 2 Kinetic of the interaction of metformin with hMATE2-K in HEK293 cells




New validated products:

  • MRP2
  • roct1


2nd German Pharm-Tox Summit
Heidelberg, Germany
March 06-09, 2017

19th Barrier- and

Bad Herrenalb, Germany
May 15-17, 2017

14th European ISSX Meeting
Köln, Germany

June 26- 29, 2017

2nd Symposium on Transporters in Drug Discovery
London, UK
May 15-16, 2017

Münster Transporttage 2017
Münster, Germany
October 21 – 22, 2017


Guidance for Industry (FDA and EMA)