PortaCellTec biosciences GmbH

MATE1

The human multidrug and toxin extrusion transporter 1 (hMATE1) is a well characterized transporter that belongs to the solute carrier family 47 (SLC47). The MATE transporter family consists of two members MATE1 (SLC47A1) and MATE2 (SLC47A2), participating in the excretion of organic cations in the kidney and liver. Although export is the presumed physiological role, depending on the intracellular and extracellular pH, MATEs may also act as uptake transporters. Typical substrates for MATEs are hydrophilic, low-molecular-weight organic cations such as metformin and 1-methy-4-phenylpyridinium (MPP), but they also transport a wide range of other compounds like acyclovir and estrone sulfate. Human MATE1 is highly expressed on the apical side of renal proximal and distal tubule cells and on the canalicular membrane of hepatocytes. There MATE1 is acting as electroneutral exchanger of its substrates with oppositely directed proton gradient as a driving force.

Figure 1 Kinetic of the interaction of MPP with hMATE1 in HEK293 cells Figure 2 Kinetic of the interaction of metformin with hMATE1 in HEK293 cells



 

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New validated products:

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2nd German Pharm-Tox Summit
Heidelberg, Germany
March 06-09, 2017

19th Barrier- and
Transporter-Meeting

Bad Herrenalb, Germany
May 15-17, 2017

14th European ISSX Meeting
Köln, Germany

June 26- 29, 2017

2nd Symposium on Transporters in Drug Discovery
London, UK
May 15-16, 2017



Münster Transporttage 2017
Münster, Germany
October 21 – 22, 2017

 


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