PortaCellTec biosciences GmbH


The human multidrug and toxin extrusion transporter 1 (hMATE1) is a well characterized transporter that belongs to the solute carrier family 47 (SLC47). The MATE transporter family consists of two members MATE1 (SLC47A1) and MATE2 (SLC47A2), participating in the excretion of organic cations in the kidney and liver. Although export is the presumed physiological role, depending on the intracellular and extracellular pH, MATEs may also act as uptake transporters. Typical substrates for MATEs are hydrophilic, low-molecular-weight organic cations such as metformin and 1-methy-4-phenylpyridinium (MPP), but they also transport a wide range of other compounds like acyclovir and estrone sulfate. Human MATE1 is highly expressed on the apical side of renal proximal and distal tubule cells and on the canalicular membrane of hepatocytes. There MATE1 is acting as electroneutral exchanger of its substrates with oppositely directed proton gradient as a driving force.

Figure 1 Kinetic of the interaction of MPP with hMATE1 in HEK293 cells Figure 2 Kinetic of the interaction of metformin with hMATE1 in HEK293 cells




New validated products:

  • mNtcp
  • mOct1


3rd German Pharm-Tox Summit
Göttingen, Germany
26 February - 1 March 2018

Saarbrücken, Germany
8 March 2018


AAPS Workshop
Virginia, USA
16 - 18 April 2018


20th Barrier- and

Bad Herrenalb, Germany
7 - 9 May 2018

Greifswalder Transporttage 2018
Greifswald, Germany
October 2018


Guidance for Industry (FDA and EMA)