PortaCellTec biosciences GmbH


Organic Anion Transporters (OATs)

  • Rizwan AN, Burckhardt G. 2007. Organic anion transporters of the SLC22 family: Biopharmaceutical, physiological, and pathological roles. Pharmaceutical Research 24:450-470.

  • Burckhardt BC, Burckhardt G. 2003. Transport of organic anions across the basolateral membrane of proximal tubule cells. Reviews of Physiology, Biochemistry and Pharmacology, Vol 146 146:95-158.

  • Sabolic I, Asif AR, Budach WE, Wanke C, Bahn A, Burckhardt G. 2007. Gender differences in kidney function. Pflugers Archiv-European Journal of Physiology 455:397-429.

  • Hagos Y, Bahn A, Vormfelde SV, Brockmoller J, Burckhardt G. 2007. Torasemide transport by organic anion transporters contributes to Hyperuricemia. Journal of the American Society of Nephrology 18:3101-3109.

  • Hagos Y, Bahn A, Vormfelde SV, Brockmoller J, Burckhardt G. 2007. Interaction of human Organic Anion Transporters with the loop diuretic torasemide and the impact on renal urate excretion. Faseb Journal 21:A909-A910.

  • Hagos Y, Stein D, Ugele B, Burckhardt G, Bahn A. 2007. Human renal organic anion transporter 4 operates as an asymmetric urate transporter. Journal of the American Society of Nephrology 18:430-439.


Organic Cation Transporters (OCTs)

  • Koepsell H, Lips K, Volk C. 2007. Polyspecific organic cation transporters: Structure, function, physiological roles, and biopharmaceutical implications. Pharmaceutical Research 24:1227-1251.

  • Koepsell H. 2004. Polyspecific organic cation transporters: their functions and interactions with drugs. Trends in Pharmacological Sciences 25:375-381.

  • Koepsell H, Endou H. 2004. The SLC22 drug transporter family. Pflugers Archiv-European Journal of Physiology 447:666-676.

  • Koepsell H, Eichelbaum M. 2003. Function and polymorphisms of organic cation transporters. Drug Metabolism Reviews 35:7.

  • Koepsell H. 1998. Organic cation transporters in intestine, kidney, liver, and brain. Annual Review of Physiology 60:243-266.


Organic Anion Transporting Polypeptides (OATP)

  • Zair ZM, Eloranta JJ, Stieger B, Kullak-Ublick GA. 2008. Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney. Pharmacogenomics 9:597-624.

  • Hagenbuch B, Gui C. 2008. Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family. Xenobiotica 38:778-801.

  • Van Montfoort JE, Hagenbuch B, Groothuis GMM, Koepsell H, Meier PJ, Meijer DKF. 2003. Drug uptake systems in liver and kidney. Current Drug Metabolism 4:185-211.


The solute carrier family SLC10

  • Geyer J, Wilke T, Petzinger E. 2006. The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. Naunyn-Schmiedebergs Archives of Pharmacology 372:413-431.





New validated products:

  • mNtcp
  • mOct1


3rd German Pharm-Tox Summit
Göttingen, Germany
26 February - 1 March 2018

Saarbrücken, Germany
8 March 2018


AAPS Workshop
Virginia, USA
16 - 18 April 2018


20th Barrier- and

Bad Herrenalb, Germany
7 - 9 May 2018

Greifswalder Transporttage 2018
Greifswald, Germany
October 2018


Guidance for Industry (FDA and EMA)