PortaCellTec - the pathfinder for your drug

Drug Transporter Assays

PortaCellTec (PCT) offers a wide range of transporter assays. All transporters are stably overexpressed in HEK293 cells (human embryonic kidney cells) and each transporter is validated with the corresponding probe substrates and inhibitors.

∇ Important clinical relevant Transporters offered by PCT

Transporter	Gene	Drug Elimination	Probe Substrates	Probe Inhibitors
OAT1	SLC22A6	renal	p-Aminohippuric acid	Probenecid, glibenclamide
OAT3	SLC22A8	renal	Estrone-3-sulfate	Probenecid, indomethacin
OATP1B1	SLCO1B1	hepatic	Estrone-3-sulfate	Rifampicin, cyclosporine, ketoconazol
OATP1B3	SLCO1B3	hepatic	Sulfobromophthalein, cholecystokinin-8 (CCK-8)	Rifampicin, cyclosporine, ketoconazol
OCT1	SLC22A1	hepatic	MPP+, Metformin	Decynium22, quinine, quinidine
OCT2	SLC22A2	renal	MPP+, Metformin	Decynium22, quinine, quinidine
MATE1	SLC47A1	hepatic/renal	MPP+, Metformin	Cimetidine, quinidine, ketoconazol
MATE2K	SLC47A2	renal	MPP+, Metformin	Cimetidine, quinidine, ketoconazol
MDR1	ABCB1	hepatic/renal	Rhodamin123	Cyclosporine, verapamil, LY335979
BCRP	ABCG2	hepatic	Estrone-3-sulfate	Ko143, elacridar, sulfosalazine
BSEP	ABCB11	hepatic	Taurocholate	Cyclosporine, glibenclamide, rifampicin

∇ All human Transporters offered by PCT

SLC Transporters

OCT1	OATP1B1	OAT1	NTCP	MATE1	NaDC1	PEPT1	SERT	OSTα-OSTβ	LAT1	NIS
OCT2	OATP1B3	OAT2	ASBT	MATE2K	NaDC3	PEPT2			LAT2
OCT3	OATP1A2	OAT3	SOAT
OCTN1	OATP2A1	OAT4
OCTN2	OATP2B1

ABC Transporters

MDR1

BCRP

BSEP

MRP2

MRP3

MRP4

∇ Transporters from other species offered by PCT

Rat (homologues gene)

roct1	roat1	rNis	rOatp1b2
roct2	roat2
roct3	roat3

Mouse (homologues gene)

moct1	moat1	mntcp	mmate1	mOatp1b2
moct2	moat2
	moat3
	moat6

mmdr1a	mbcrp		mmrp2
mmdr1b