Drug Transporter Assays

PortaCellTec (PCT) offers a wide range of transporter assays. All transporters are stably overexpressed in HEK293 cells (human embryonic kidney cells) and each transporter is validated with the corresponding probe substrates and inhibitors.

∇    Important clinical relevant Transporters offered by PCT
Transporter
Gene
Drug Elimination
Probe Substrates
Probe Inhibitors
SLC22A6
renal
p-Aminohippuric acid
Probenecid, glibenclamide
SLC22A8
renal
Estrone-3-sulfate
Probenecid, indomethacin
SLCO1B1
hepatic
Estrone-3-sulfate
Rifampicin, cyclosporine, ketoconazol
SLCO1B3
hepatic
Sulfobromophthalein, cholecystokinin-8 (CCK-8)
Rifampicin, cyclosporine, ketoconazol
SLC22A1
hepatic
MPP+, Metformin
Decynium22, quinine, quinidine
SLC22A2
renal
MPP+, Metformin
Decynium22, quinine, quinidine
SLC47A1
hepatic/renal
MPP+, Metformin
Cimetidine, quinidine, ketoconazol
SLC47A2
renal
MPP+, Metformin
Cimetidine, quinidine, ketoconazol
ABCB1
hepatic/renal
Rhodamin123
Cyclosporine, verapamil, LY335979
ABCG2
hepatic
Estrone-3-sulfate
Ko143, elacridar, sulfosalazine
ABCB11
hepatic
Taurocholate
Cyclosporine, glibenclamide, rifampicin

∇    All human Transporters offered by PCT

SLC Transporters

SERT
OCTN1
OATP2A1



ABC Transporters

MRP3
MRP4

∇    Transporters from other species offered by PCT

Rat (homologues gene)




Mouse (homologues gene)

moat2
moat6







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