PortaCellTec biosciences GmbH

Substrate studies


PortaCellTec offers three possibilities to measure substrate transporter interactions:

  1. Quantification of substrate uptake with radio-labeled substrates

 
  2. Quantification of substrate uptake with fluorescent substrates  

  3.

Quantification of non-labeled substrate uptake by LC-MS/MS
(we provide this service together with a cooperation partner)
New


First Step

Time and concentration dependent uptake of a test item is performed in the absence and presence of a probe inhibitor.




Second Step

Determination of Km and Vmax value: Concentration dependent uptake of a labeled test item to determine the affinity (Km value) and the maximum transport rate (Vmax) of a transporter for a test item.

Km determination

 

Service


Drug transporter assays

  Study design

  Assay performance

  Inhibition studies

  Substrate studies


Additional service

Partnered service

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PortaCellTec Biosciences GmbH

 

Weender Landstraße 94 -108
37075 Göttingen
Tel : +49 551 309 66440
E-mail: PortaCellTec




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PortaCellTec

News

New validated products:

  • MRP2
  • roct1

Events

2nd German Pharm-Tox Summit
Heidelberg, Germany
March 06-09, 2017

19th Barrier- and
Transporter-Meeting

Bad Herrenalb, Germany
May 15-17, 2017

14th European ISSX Meeting
Köln, Germany

June 26- 29, 2017

2nd Symposium on Transporters in Drug Discovery
London, UK
May 15-16, 2017



Münster Transporttage 2017
Münster, Germany
October 21 – 22, 2017

 


Guidance for Industry (FDA and EMA)

Publications