PortaCellTec biosciences GmbH

Substrate studies

PortaCellTec offers three possibilities to measure substrate transporter interactions:

  1. Quantification of substrate uptake with radio-labeled substrates

  2. Quantification of substrate uptake with fluorescent substrates  


Quantification of non-labeled substrate uptake by LC-MS/MS
(we provide this service together with a cooperation partner)

First Step

Time and concentration dependent uptake of a test item is performed in the absence and presence of a probe inhibitor.

Second Step

Determination of Km and Vmax value: Concentration dependent uptake of a labeled test item to determine the affinity (Km value) and the maximum transport rate (Vmax) of a transporter for a test item.

Km determination



Drug transporter assays

  Study design

  Assay performance

  Inhibition studies

  Substrate studies

Additional service

Partnered service

Download PortaCellTec

PortaCellTec Biosciences GmbH


Weender Landstraße 94 -108
37075 Göttingen
Tel : +49 551 309 66440
E-mail: PortaCellTec

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New validated products:

  • mNtcp
  • mOct1


3rd German Pharm-Tox Summit
Göttingen, Germany
26 February - 1 March 2018

Saarbrücken, Germany
8 March 2018


AAPS Workshop
Virginia, USA
16 - 18 April 2018


20th Barrier- and

Bad Herrenalb, Germany
7 - 9 May 2018

Greifswalder Transporttage 2018
Greifswald, Germany
October 2018


Guidance for Industry (FDA and EMA)