PortaCellTec biosciences GmbH

PortaCellTec – the pathfinder for your drug

Drug transporter service

PortaCellTec (PCT) provides a broad spectrum of uptake and efflux transporter assays (e.g. OATs, OCTs, OATPs, MATEs, MDR1, BCRP, BSEP, MRPs) to investigate the inhibitory potential and substrate characteristics of your drug. As recommended by FDA and EMA, we perform in vitro transporter studies with validated drug transporters stably-transfected in HEK-293 cells.


New! Quantification of non-labeled substances by LC/MS




Efflux transporter service


Gene name Protein name Probe substrates Probe inhibitors Transporter assays
ABCB1 MDR1 rhodamine123 verapamil,
cyclosporineA,
LY335979
efflux transporter assay
ABCG2 BCRP estrone-3- sulfate Ko143, elacridar,
sulfosalazine
vesicle-based
transporter assay
ABCB11 BSEP taurocholate cyclosporineA,
glibenclamide,
rifampicin
vesicle-based
transporter assay
ABCC2 MRP2 CDCF MK-571
benzbromarone
efflux transporter assay



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PortaCellTec Biosciences GmbH

 

Weender Landstraße 94 -108
37075 Göttingen
Tel : +49 551 309 66440
E-mail: PortaCellTec



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PortaCellTec

News

New validated products:

  • mNtcp
  • mOct1

Events

3rd German Pharm-Tox Summit
Göttingen, Germany
26 February - 1 March 2018


Pharmaforum
Saarbrücken, Germany
8 March 2018

 

AAPS Workshop
Virginia, USA
16 - 18 April 2018

 

20th Barrier- and
Transporter-Meeting

Bad Herrenalb, Germany
7 - 9 May 2018

Greifswalder Transporttage 2018
Greifswald, Germany
October 2018

 


Guidance for Industry (FDA and EMA)

Publications

 

 

PortaCellTec